學(xué)術(shù)論文
1. Xiong Y, Jing XP, Zhou XW, Wang XL, Yang Y, Sun XY, Qiu M, Cao FY, Lu YM, Liu R*, Wang JZ*.Zinc induces protein phosphatase 2Ainactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation.Neurobiol Aging. 2012 Aug 11. [Epub ahead of print] PubMed PMID: 22892311 （* 通訊作者）
2. Sun XY, Wei YP, Xiong Y,Wang XC, Xie AJ, Wang XL, Yang Y, Wang Q, Lu YM, Liu R*, Wang JZ. Synapticreleased zinc promotes tau hyperphosphorylation by inhibition of PP2A. J Biol Chem.2012,287(14):11174-11182. （* 通訊作者）
3. Liu R*,
Wang JZ. Proteinphosphatase 2A inAlzheimer's disease. Pathophysiology. 2009 Oct;16(4):273-7. （* 通訊作者）4. Liu R
, Zhou XW, Tanila H,Bjorkdahl C, Wang JZ, Guan ZZ, Cao Y, Gustafsson JA,Winblad B, Pei JJ. Phosphorylated PP2A (tyrosine 307) is associated withAlzheimer neurofibrillary pathology. J Cell Mol Med. 2008,12(1):241-57.5. Liu R
, Zeng J, Zhou XW, PeiJJ, Wang JZ. Effect of inhibiting tyrosine kinase Src expression on proteinphosphatase 2A and tauphosphorylation. Frontiers of Medicine in China.2008,2,235-238.6. Liu R,
Pei JJ,Wang XC,Zhou XW, Tian Q, Winblad B,Wang JZ. Anoxia induces tau dephosphorylation through protein phosphatase-2A activation in rat brain slices.J Neurochem 2005,Sep;94(5):1225-1234. 7. 劉蓉
，王小川，黃堯，何志松，楮淑娟，湯蕓，田青，王建枝. 急性缺氧和急性低糖對腦片tau蛋白磷酸化的影響。生物化學(xué)和生物物理進展2004,31(5): 402-408.8. LiuR,
Wang XC, ZhouXW, Fang ZY, Tian Q, Pei JJ, Wang JZ. Acute hypoxia induces dephosphorylationof Tau in rat brain slices.Neurobiology Aging2004,25(2):432 (Abs)9. Yu G, Li Y, Tian Q,
Liu R
, Wang Q, Wang JZ, Wang X. Berberineattenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation inHEK293 cells. J Alzheimers Dis. 2011 Jan 1;24(3):525-35.10. Wang HH, Li HL
, Liu R
,Zhang Y, Liao K, Wang Q, Wang JZ, Liu SJ. Tau overexpression inhibits cellapoptosis with the mechanisms involving multiple viability-related factors. JAlzheimers Dis. 2010 Jan;21(1):167-79.11. Liu XA, Liao K,
Liu R
,Wang HH, Zhang Y, Zhang Q, Wang Q, Li HL, Tian Q, Wang JZ. Tau DephosphorylationPotentiates Apoptosis with the Mechanisms Involving a FailedDephosphorylation/Activation of Bcl-2. J Alzheimers Dis. 2010;19(3):953-6212. Zhou XW, Gustafsson JA,Tanila H, Bjorkdahl C,
Liu R
, Winblad B, Pei JJ. Tauhyperphosphorylation correlates with reduced methylation of protein phosphatase2A.Neurobiol Dis.2008,31(3):386-394.13. Wang Q, Tian Q,
Liu R
, Liu zz, Hu mq, Ke D, Zhang sh; Wang xc. Pre-treatment with melatonin inhibits oleic acid-induced acute lung injury in rats.Chinese Journal of Pathophysiology. 2007, 4, 767-771.14. Fang J,
Liu R
, Tian Q, Hong XP, Wang SH, Cao FY, Pan XP, Wang JZ. Dehydroevodiamine attenuates calyculin A-induced tau hyperphosphorylation in rat brain slices.Acta Pharmacol Sin. 2007,28(11):1717-23.15. Wang SH, Zhu LQ, Shi HR, Zheng HY, Wang Q,
Liu R
, Wang JZ, Inhibition of Melatonin Biosynthesis Induces Neurofilament Hyperphosphorylation with Activation of Cyclin-dependent Kinase 5.Neurochemical Research 2007, 32(8):1329-1335.16. An WL, Bjorkdahl C,
Liu R
, Cowburn RF, Winblad B, Pei JJ. Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3β in SH-SY5Y neuroblastoma cells.J Neurochem 2005,92(5):1104-1115.17. HuZH, Wang XC, Li LY, Liu ML,
Liu R
, Ling Z, Tian Q, Tang XW, Wu YG, WangJZ. Correlation of behavior changes and BOLD signal in Alzheimer-like ratmodel.Acta Biochim Biophys Sin (Shanghai) 2004,36(12):803-810.18. FangZY, Liu SJ, Wang XC,
Liu R,
Wang Q, Chen ZY, Wang JZ. Effect of calpainon the degradation of tau protein in rat brain cortex extracts.Sheng Wu HuaXue Yu Sheng Wu Wu Li Xue Bao; 2003,35(7): 629-634.19. SunL, Liu SY, Zhou XW, Wang XC,
Liu R
, Wang Q, Wang JZ. Inhibition ofprotein phosphatase 2A andprotein phosphatase 1-induced tau hyperphosphorylation and impairment ofspatial memory retention in rats.Neuroscience; 2003,118(4):1175-1182.20. WangJZ, Wang XC,
Liu R
, Wang Q, Grundke-Iqbal I.Iqbal K. In vitro analysisof tau phosphorylation sites and its biological activity.Acta AcademiaeMedicinae Sinicae; 2002,17(1):13-16.科研項目
2013-2016 國家自然科學(xué)基金700,000 RMB Tau-PP2A-Src 復(fù)合體對NMDA 受體的異常調(diào)控在阿爾茨海默病發(fā)生中的作用 項目負(fù)責(zé)人
2013-2016 國家自然科學(xué)基金中加老年癡呆癥及相關(guān)病癥合作研究項目3,000,000 RMB GSK-3 介導(dǎo)Aβ, tau 和胰島素相關(guān)阿爾茨海默樣突觸和膽堿能損傷的機制研究 第二完成人
2012-2013 華中科技大學(xué)自主創(chuàng)新研究基金50,000 RMB CIP2A對PP2A 的調(diào)節(jié)及其在阿爾茨海默病發(fā)病中的作用項目負(fù)責(zé)人
2010-2012 華中科技大學(xué)自主創(chuàng)新研究基金 70,000 RMB 鋅離子對蛋白磷酸酯酶2A的調(diào)節(jié)和機制 項目負(fù)責(zé)人
2009-2011 國家自然科學(xué)基金200,000 RMB 下調(diào)磷酸酯酶抑制因子對老年性癡呆的保護作用及機制研究 第二完成人
2009-2011 國家自然科學(xué)基金80,000 RMB SET核轉(zhuǎn)運及其對PP2A活性影響 第二完成人
2009-2011 國家自然科學(xué)基金200,000 RMB 白質(zhì)星形膠質(zhì)細(xì)胞內(nèi)S100A4 蛋白抑制DRG神經(jīng)元突起生長的機理研究 第二完成人
2006-2008 國家自然科學(xué)基金240,000 RMB 蛋白磷酸脂酶2A的酪氨酸磷酸化修飾在AD發(fā)病中的作用 項目負(fù)責(zé)人
2005-2006 瑞典Stiftelsen Gamlatj渀愀爀椀渀渀漀爀基金 30,000 Kr 項目負(fù)責(zé)人
2005-2006 瑞典Gun Och Bertil StohnesStifielse基金 25,000 Kr 項目負(fù)責(zé)人
2000-2001 同濟醫(yī)學(xué)院青年基金（姜學(xué)誼基金）3,000 RMB 項目負(fù)責(zé)人
獲獎情況
急性能量代謝障礙對微管相關(guān)蛋白Tau的影響 2005年獲湖北省優(yōu)秀碩士學(xué)位論文獎
蛋白磷酸酯酶2A的酪氨酸磷酸化修飾在Alzheimer病發(fā)病中的作用 2008年獲湖北省優(yōu)秀博士學(xué)位論文獎
蛋白激酶在阿爾茨海默病tau蛋白過度磷酸化中的作用及應(yīng)用價值 2008年獲中華醫(yī)學(xué)科技獎二等獎
Tau蛋白過度磷酸化的機制及其對神經(jīng)元生存命運的影響 2009年獲教育部高等學(xué)?？茖W(xué)研究優(yōu)秀成果獎自然科學(xué)獎一等獎
2008年獲華中科技大學(xué)青年教師講課比賽二等獎
Phosphorylated PP2A (tyrosine 307) is associated with Alzheimerneurofibrillary pathology，2010年獲武漢市首屆優(yōu)秀學(xué)術(shù)論文獎
